By the close of the eighteenth century, most Native Americans living along the Eastern Seaboard and into Central Plains had been impacted by the American colonists. Suffering increasing demands on lands and resources, many Native Americans were displaced into territories occupied by other tribes. Trade in horses, gunpowder weapons, and furs had both benefited and corroded Native populations as wars over territory became increasingly more frequent and violent. Along with trade came new diseases for which Native Americans had neither immunity nor experience in treating. As tribes experienced conquest, starvation, or illness, members of smaller tribes were sometimes adopted into new communities.