The history of relations between Native Americans and European, and later American, settlers was marked by conflict. At the root of the numerous wars were disputes over the control of territory and resources. Strife was compounded by widely different cultures and economic systems. As the American colonists and settlers moved into the western regions, they displaced Native Americans and altered or destroyed indigenous biosystems and replaced them with new agricultural or industrial structures. For instance, in Jamestown, the first permanent British colony in what would become the United States, the cultivation of tobacco by settlers supplanted hunting and small-scale farming by the native Powhatan people as the colonists expanded Westward.